Can a gene providing health blessing or a curse disease? Apparently it is very possible depending on the genetic inheritance of the father or mother.
The team of researchers from Iceland joined in Iceland 's Decode Genetics Inc. discovered the gene mutation in the five diseases that affect only if inherited from a particular parent.
A new gene associated with diabetes can protect a person from the disease, if inherited from the mother, but increases the risk if inherited from the father.
Three other genes diabetes varied effect though not too dependent on the origin of their parents genes. Researchers have reported these findings in the journal Nature.
"We can make this discovery because we are in a unique position, in order to distinguish between what is inherited from the mother and what he inherited from his father," said Kari Stefansson, Decode's Chief Executive Officer as quoted by Reuters on Thursday (17/12/2009) .
Researchers found a gene that would increase slightly the risk of breast cancer when inherited from the father but has no effect or may even protect when inherited from the mother.
A gene of skin cancer called basal-cell carcinoma of the slower growth was far more dangerous when inherited from the father.
Researchers also found a gene variation with type 2 diabetes (diabetes due to obesity or lifestyle), called single nucleotide polymorphism (SNP) which experienced a change in the genetic code.
"The impact of variations in type-2 diabetes is not only big but also not unusual. If an individual inherits from his father the increased risk of diabetes variant could be more than 30 percent. If inherited from the maternal line of the risk variant is down more than 10 percent, "he explained.
In this study, researchers examined 38,167 people of Iceland , because they have inherited a unique gene that has little changed since the Vikings arrived in the country more than 1,000 years ago.
Every person has two copies of every gene, one from the father and one from the mother. A process called imprinting affects the current version of the gene for the growth and development